3D In Vitro  Tissue Engineered Models and Microreactors for Drug Development

Most tissues and organs require blood flow both for distribution of nutrients and growth factors as well as mechanical stimulation and provision of trafficking of cells.  We have developed and commercialized a microscale perfusion reactor, LiverChip, to support 3D liver culture, including support of delicate liver sinusoidal endothelial cells [1-5]. We are currently focused on creating more complex tissue microstructures through use of functional biomaterials and projection microstereolithography and applying the liver system to a variety of important physiology and drug development problems including liver inflammation and drug toxicity, and as a model of single cell cancer metastasis growth and response to chemotherapy.